HIPEC Study
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

Disease site

Ovary

Publication month/year

Jan 2018

Study question

To investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial cancer.

Type of study

Multicenter, open-label, phase 3, randomized clinical trial (RCT)

Interventions compared

Interval cytoreductive surgery vs Interval cytoreductive surgery with HIPEC

Experimental arm (Intervention)

Interval cytoreductive surgery with HIPEC with cisplatin (100mg per square meter)

Control arm

Interval cytoreductive surgery

Primary outcome

Recurrence-free survival

Secondary outcome
  • Overall survival¬†
  • Side-effect profile
Inclusion criteria
  • Newly diagnosed stage III epithelial ovarian, fallopian tube, or peritoneal cancer who were referred for neoadjuvant chemotherapy
  • WHO performance status score of 0 to 2
  • Normal blood counts
  • Adequate renal function
Exclusion criteria

Cases that did not meet the inclusion criteria were excluded 

Results
Surgery-plus-HIPEC group Surgery group
Randomised (n)
122
123
Received treatment
118
122
Recurrence-free survival (months)
14.2
10.7
Overall survival (months)
45.7
33.9
Adverse events of grade 3 or 4
27%
25%
Conclusions

The addition of Hyperthermic Intraperitoneal Chemotherapy to interval cytoreductive surgery resulted in longer recurrence-free survival and overall survival, and did not result in higher rates of side effects.

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