Key Study Summaries
What are the key study summaries?
In every speciality there are studies that shape the way how we mange certain conditions; these studies are called key studies. Knowledge of and understanding the key studies, as well as critically appraising them, is key to safe and successful management. We launched the key study summaries project with the aim to bring all the important studies in gynaecology to one place and make it easily accessible no matter where you are.
We are always looking for authors to contribute in the key study summaries and other projects. If you wish to submit your contribution please follow the link. We look forward hearing from you.
Cervical cancer
Cervical Cancer
LACC Study
Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical cancer
Cervical Cancer
GOG-120 Study
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
Cervical Cancer
GOG-240 Study
Improved Survival with Bevacizumab in Advanced Cervical Cancer
Bulky stage IB cervical carcinoma May/1999
A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy
Bulky stage IB cervical carcinoma April/1999
Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma
High-Risk Early-Stage Cancer of the Cervix GOG109
Concurrent Chemotherapy and Pelvic Radiation Therapy Compared with Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix.
Cervical Cancer (GOG 92)
To determine whether postoperative pelvic radiotherapy following radical hysterectomy and pelvic node dissection would reduce the rate of reoccurrence and decrease mortality in Stage IB cancer patients.
Ovarian cancer
Ovarian Cancer
ICON1 Study
International Collaborative Ovarian Neoplasm Trial 1
Ovarian Cancer
CHORUS Study
Neoadjuvant Chemotherapy/Interval Debulking Surgery Vs Primary Debulking Surgery in Advanced Ovarian Cancer
Ovarian Cancer
EORTC55971 Study
Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer
Advanced ovarian CA (MITO-7)
Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7)
Advanced Ovarian Cancer (GOG-178)
Phase III Randomized Trial of 12 Versus 3 Months of Maintenance Paclitaxel in Patients with Advanced Ovarian Cancer After Complete Response to Platinum and Paclitaxel-Based Chemotherapy
Ovarian Cancer
Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer
HIPEC in Ovarian Cancer
To investigate whether the addition of (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial cancer
Ovarian Cancer
ACTION Trial
Impact of Adjuvant Chemotherapy and Surgical Staging in Early-Stage Ovarian Carcinoma
Ovarian cancer ICON7 study
A Phase 3 Trial of Bevacizumab in Ovarian Cancer. The study question was to investigate the addition of bevacizumab to standard chemotherapy in the first-line treatment of ovarian cancer.
Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer GOG172
The study question was to test the effectiveness of intraperitoneal Cisplatin and Paclitaxel in addition to intravenous Paclitaxel in women with stage III ovarian cancer who had optimal debulking surgery.
Ovarian Cancer (GOG 182)
Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer
Ovarian Cancer (PAOLA-1)
Assessing the effects of Olaparib in combination with bevacizumab on disease progression as first-line maintenance in Ovarian Cancer
uterine cancer
Uterine Cancer
LACE Study
Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival Among Women With Stage I Endometrial Cancer
Endometrial carcinoma GOG 122
Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study
Uterine Cancer
LAP2 Study
Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2
Uterine Cancer
PORTEC-1 Study
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multi-centre randomised trial
Uterine Cancer
ASTEC Study
Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study
Intermediate- and high-risk endometrial cancer JGOG 2008
Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer JGOG 2008
Advanced Endometrial Cancer GOG258
Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer (GOG258). The study question was to evaluate the use of chemoradiotherapy as compared with the use of chemotherapy alone in locally advanced endometrial cancer.
Endometrial Cancer (GOG 249)
To determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival compared with pelvic radiation therapy (RT) in high-risk early-stage endometrial carcinoma
vulvar cancer
Vulvar Cancer
SNL Study 2008
Sentinel Node Dissection Is Safe in the Treatment of Early-Stage Vulvar Cancer
Vulvar Cancer
GOG 173
Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women With Squamous Cell Carcinoma of the Vulva: A Gynecologic Oncology Group Study
gestational trophoblastic neoplasia
Second Curettage for Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia (GOG 242)
To define the efficacy and safety of second curettage in patients with persistent, nonmetastatic low-risk GTN
Low-Risk Gestational Trophoblastic Neoplasia
Phase III Trial of Weekly Methotrexate or Pulsed Dactinomycin for Low-Risk Gestational Trophoblastic Neoplasia: A Gynecologic Oncology Group Study
What You Get
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