Cervical Cancer Studies

GOG 85 Study

GOG 85 StudyRandomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10334517/ Publication month/year May 1999 Study question Determine the superior chemoradiation regimen between …

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Randomized study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer (LANDONI)

LANDONI StudyRandomized study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/9284774/ Publication month/year August 1997 Study question To compare the efficacy of radial surgery with pelvic radiation for the treatment of newly diagnosed stage Ib -IIa cervical cancer Type of study Randomised controlled trial (RCT) Interventions compared …

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A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study (GOG 92)

GOG 92 StudyA randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10329031/ Publication month/year May 1999 Study question To determine whether postoperative pelvic radiotherapy following radical hysterectomy and pelvic node dissection would …

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study (GOG 92) Read More »

Concurrent Chemotherapy and Pelvic Radiation Therapy Compared with Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix. (GOG 109)

GOG 109 StudyConcurrent Chemotherapy and Pelvic Radiation Therapy Compared with Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix. Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10764420/ Publication month/year February, 2000 Study question To evaluate if the addition of Cisplatin (with or without fluorouracil) chemotherapy to standard pelvic radiation …

Concurrent Chemotherapy and Pelvic Radiation Therapy Compared with Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix. (GOG 109) Read More »

Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma

GOG 123 StudyCisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10202166/ Publication month/year April / 1999 Study question To determine whether concurrent weekly treatment with cisplatin during radiotherapy would improve progression-free survival and survival in women with large “bulky,” or barrel-shaped, …

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A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10329031/ Publication month/year May, 1999 Study question To determine whether postoperatice pelvic radiotherapy following radial hysterectomy and pelvic …

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study Read More »

Improved Survival with Bevacizumab in Advanced Cervical Cancer (GOG240)

GOG 240 StudyImproved Survival with Bevacizumab in Advanced Cervical Cancer Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/24552320/ Publication month/year February/2014 Study question Evaluation the effectiveness of bevacizumab and nonplatinum combination chemotherapy in patients with recurrent, persistent, or metastatic cervical cancer. Type of study RCT: 2-by-2 factorial design. Interventions compared  Cisplatin and paclitaxel vs. Topotecan and paclitaxel. …

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GOG-120 Study

GOG 120 Study Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10202165/ Publication month/year April 1999 Study question Do regimens of radiotherapy and chemotherapy that contain cisplatin improve the rates of survival and progression-free survival among women with locally advanced cervical cancer? Type of study Randomised controlled trial …

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LACC Study

LACC Study Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/30380365/ Publication month/year November 2018 Study question Is minimally invasive radical Hysterectomy inferior to open radical hysterectomy in terms of disease free survival rate for early stage cervical cancer? Type of study Randomised controlled trial (RCT) Interventions compared Minimally Invasive Approach (Laparascopic or Robotic) Vs Open in Abdominal …

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