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Phase III Trial of Weekly Methotrexate or Pulsed Dactinomycin for Low-Risk Gestational Trophoblastic Neoplasia: A Gynecologic Oncology Group Study

GOG 174 Study Phase III Trial of Weekly Methotrexate or Pulsed Dactinomycin for Low-Risk Gestational Trophoblastic Neoplasia: A Gynecologic Oncology Group Study Disease site Uterus “Gestational Trophoblastic Neoplasia (GTN)” Pubmed link https://pubmed.ncbi.nlm.nih.gov/21263100/ Publication month/year March 2011 Study question The best regimen for the primary treatment of low-risk GTN Type of study Phase III Randomized Clinical …

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Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

HIPEC Study Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/29342393/ Publication month/year Jan 2018 Study question To investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial cancer. Type of study Multicenter, open-label, phase …

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Advanced Ovarian Cancer (GOG-178)

GOG 178 Study Phase III Randomized Trial of 12 Versus 3 Months of Maintenance Paclitaxel in Patients with Advanced Ovarian Cancer After Complete Response to Platinum and Paclitaxel-Based Chemotherapy: A Southwest Oncology Group and Gynecologic Oncology Group Trial Disease site Ovaries  Pubmed link https://pubmed.ncbi.nlm.nih.gov/12829663/ Publication month/year July, 2003 Study question To verify whether continuing paclitaxel …

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Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): A randomized, multicentre, open-label, phase 3 trial

MITO-7 StudyCarboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer; A randomized, multicentre, open-label, phase 3 trial Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/24582486/ Publication month/year February, 2014 Study question To assess whether a weekly schedule of carboplatin plus paclitaxel is more effective than the same drug combination given …

Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): A randomized, multicentre, open-label, phase 3 trial Read More »

Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma

GOG 123 StudyCisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10202166/ Publication month/year April / 1999 Study question To determine whether concurrent weekly treatment with cisplatin during radiotherapy would improve progression-free survival and survival in women with large “bulky,” or barrel-shaped, …

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A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10329031/ Publication month/year May, 1999 Study question To determine whether postoperatice pelvic radiotherapy following radial hysterectomy and pelvic …

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study Read More »

Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer

VELIA Study Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/31562800/ Publication month/year September 2019 Study question Efficacy of Veliparib added to first-line induction chemotherapy with carboplatin and paclitaxel and continued as maintenance monotherapy in patients with previously untreated stage III or IV high-grade serous ovarian carcinoma. …

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Improved Survival with Bevacizumab in Advanced Cervical Cancer (GOG240)

GOG 240 StudyImproved Survival with Bevacizumab in Advanced Cervical Cancer Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/24552320/ Publication month/year February/2014 Study question Evaluation the effectiveness of bevacizumab and nonplatinum combination chemotherapy in patients with recurrent, persistent, or metastatic cervical cancer. Type of study RCT: 2-by-2 factorial design. Interventions compared  Cisplatin and paclitaxel vs. Topotecan and paclitaxel. …

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GOG-173

GOG 173 Study Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women With Squamous Cell Carcinoma of the Vulva: A Gynecologic Oncology Group Study Disease site Vulva  Pubmed link https://pubmed.ncbi.nlm.nih.gov/22753905/ Publication month/year July 2012 Study question Is it safe to do sentinel lymph node biopsy as a replacement for inguinal femoral lymphadenectomy in selected women …

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SLN Vulva Cancer Study 2008

SLN Vulvar Cancer Study 2008 Sentinel node dissection is safe in the treatment of early-stage vulvar cancer Disease site Vulva  Pubmed link https://pubmed.ncbi.nlm.nih.gov/18281661/ Publication month/year February 2008 Study question The safety of omitting inguinofemoral lymphadenectomy in patients with a negative sentinel node. Compare short- and long-term morbidity between sentinel node removal only and inguinofemoral lymph …

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