GOG 120 Study Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10202165/ Publication month/year April 1999 Study question Do regimens of radiotherapy and chemotherapy that contain cisplatin improve the rates of survival and progression-free survival among women with locally advanced cervical cancer? Type of study Randomised controlled trial …
LACC Study Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/30380365/ Publication month/year November 2018 Study question Is minimally invasive radical Hysterectomy inferior to open radical hysterectomy in terms of disease free survival rate for early stage cervical cancer? Type of study Randomised controlled trial (RCT) Interventions compared Minimally Invasive Approach (Laparascopic or Robotic) Vs Open in Abdominal …
ACTION Study Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/12529344/ Publication month/year 2003 January Study question To comare the outcome platinum-based adjuvant chemotherapy with no further treatment (i.e., observation) following surgery in patients with early-stage ovarian cancer who had adequate surgical stage. Type of study Randomised controlled trial (RCT) Interventions compared Chemotherapy vs Observation Experimental arm (Intervention) …
ICON1 Study International Collaborative Ovarian Neoplasm Trial 1: A Randomized Trial of Adjuvant Chemotherapy in Women With Early-Stage Ovarian Cancer (ICON1) Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/12529345/ Publication month/year January 2003 Study question Can adjuvant chemotherapy improve overall survival and prolong recurrence-free survival in women with early-stage epithelial ovarian cancer? Type of study Randomised controlled …
PORTEC-1 Study Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multi-centre randomised trial Disease site uterus Pubmed link https://pubmed.ncbi.nlm.nih.gov/10791524 Publication month/year April 2000 Study question To find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma Type of study Randomised controlled trial (RCT) Interventions …
ASTEC Study Efficacy of Systematic Pelvic Lymphadenectomy in Endometrial Cancer (MRC ASTEC Trial): A Randomised Study Disease site Uterine Pubmed link https://pubmed.ncbi.nlm.nih.gov/19070889/ Publication month/year January 2009 Study question Can pelvic lymphadenectomy improve survival of women with early endometrial cancer independent of the effect of adjuvant therapy Type of study Randomised controlled trial (RCT) Interventions compared …
LACE Study Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival Among Women With Stage I Endometrial Cancer: A Randomized Clinical Trial LACE Disease site Uterine Pubmed link https://pubmed.ncbi.nlm.nih.gov/28350928/ Publication month/year March 2017 Study question To investigate whether total laparoscopic hysterectomy is equivalent to total abdominal hysterectomy in women with treatment naive …
LAP2 Study Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2 Disease site Uterine Pubmed link https://pubmed.ncbi.nlm.nih.gov/19805679 Publication month/year October 2009 Study question Laparoscopy vs. laparotomy in achieving best outcomes regarding complete comprehensive surgical staging of uterine cancer Type of study Randomised controlled trial (RCT) Interventions compared Laparoscopic …
CHORUS Study Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/26002111 Publication month/year May 2015 Study question Is Neoadjuvant Chemotherapy (NACT) followed by Interval Debulking Surgery (IDS) non-inferior to Primary Debulking Surgery (PDS) Type of study Randomised controlled trial (RCT) …
EORTC55971 Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/20818904/ Publication month/year September 2010 Study question Primary debulking surgery (PDS) followed chemotherapy vs neoadjuvant chemotherapy followed by interval debulking surgery (NACT/IDS) in women with advanced ovarian Type of study Randomised controlled trial (RCT) Interventions compared PDS …
