Endometrial Cancer Studies

GOG 249 Study Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer Disease site Uterus Pubmed link https://www.ncbi.nlm.nih.gov/pubmed/?term=30995174 Publication month/year July 2019 Study question To determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival compared with pelvic radiation therapy (RT) in high-risk …

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer (GOG 249) Read More »

GOG 122 Study Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study Disease site Uterus Pubmed link https://pubmed.ncbi.nlm.nih.gov/16330675/ Publication month/year January 2006 Study question To compare whole-abdominal irradiation and chemotherapy in women with stage III or IV endometrial carcinoma Type of study Randomised …

Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study (GOG122) Read More »

GOG 258 Study Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer Disease site Uterus Pubmed link https://pubmed.ncbi.nlm.nih.gov/31189035/ Publication month/year June 2019 Study question To evaluate the use of chemoradiotherapy as compared with the use of chemotherapy alone in locally advanced endometrial cancer Type of study  Phase 3 RCT Interventions compared Chemoradiotherapy vs Chemotherapy Experimental …

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JGOG 2008 Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer Disease site Uterine Pubmed link https://pubmed.ncbi.nlm.nih.gov/17996926/ Publication month/year November 2007 Study question To establish an optimal adjuvant therapy for intermediate- and high-risk endometrial cancer patients Type of study Randomized Controlled Trial (RCT) Interventions compared …

Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer JGOG 2008 Read More »

PORTEC-1 Study Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multi-centre randomised trial Disease site uterus Pubmed link https://pubmed.ncbi.nlm.nih.gov/10791524 Publication month/year April 2000 Study question To find whether postoperative pelvic radiotherapy improves locoregional control and survival for patients with stage-1 endometrial carcinoma Type of study Randomised controlled trial (RCT) Interventions …

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ASTEC Study Efficacy of Systematic Pelvic Lymphadenectomy in Endometrial Cancer (MRC ASTEC Trial): A Randomised Study Disease site Uterine  Pubmed link https://pubmed.ncbi.nlm.nih.gov/19070889/ Publication month/year January 2009 Study question Can pelvic lymphadenectomy improve survival of women with early endometrial cancer independent of the effect of adjuvant therapy Type of study Randomised controlled trial (RCT) Interventions compared …

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LACE Study Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival Among Women With Stage I Endometrial Cancer: A Randomized Clinical Trial LACE Disease site Uterine  Pubmed link https://pubmed.ncbi.nlm.nih.gov/28350928/ Publication month/year March 2017 Study question To investigate whether total laparoscopic hysterectomy is equivalent to total abdominal hysterectomy in women with treatment naive …

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LAP2 Study Laparoscopy Compared With Laparotomy for Comprehensive Surgical Staging of Uterine Cancer: Gynecologic Oncology Group Study LAP2 Disease site Uterine Pubmed link https://pubmed.ncbi.nlm.nih.gov/19805679 Publication month/year October 2009 Study question Laparoscopy vs. laparotomy in achieving best outcomes regarding complete comprehensive surgical staging of uterine cancer Type of study Randomised controlled trial (RCT) Interventions compared Laparoscopic …

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