Mo Daas

GOG 85 Study

GOG 85 StudyRandomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10334517/ Publication month/year May 1999 Study question Determine the superior chemoradiation regimen between …

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Randomized study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer (LANDONI)

LANDONI StudyRandomized study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/9284774/ Publication month/year August 1997 Study question To compare the efficacy of radial surgery with pelvic radiation for the treatment of newly diagnosed stage Ib -IIa cervical cancer Type of study Randomised controlled trial (RCT) Interventions compared …

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A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study (GOG 92)

GOG 92 StudyA randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy Disease site Cervix Pubmed link https://pubmed.ncbi.nlm.nih.gov/10329031/ Publication month/year May 1999 Study question To determine whether postoperative pelvic radiotherapy following radical hysterectomy and pelvic node dissection would …

A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study (GOG 92) Read More »

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer (GOG 249)

GOG 249 Study Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer Disease site Uterus Pubmed link https://www.ncbi.nlm.nih.gov/pubmed/?term=30995174 Publication month/year July 2019 Study question To determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival compared with pelvic radiation therapy (RT) in high-risk …

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer (GOG 249) Read More »

Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup (GOG 182)

GOG 182 Study Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/19224846/ Publication month/year March 2009 Study question Does incorporation of an additional cytotoxic agent improve overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian …

Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup (GOG 182) Read More »

Second Curettage for Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia (GOG242)

GOG 242 Study Second Curettage for Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia Disease site Uterus Pubmed link https://pubmed.ncbi.nlm.nih.gov/27500329/ Publication month/year September 2016 Study question To define the efficacy and safety of second curettage in patients with persistent, nonmetastatic low-risk GTN Type of study Prospective two-stage single arm phase II study Intervention (single arm) Second Curettage for …

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Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer (PAOLA-1)

PAOLA-1 Study Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer Disease site Ovaries¬† Fallopian tube Primary peritoneal Pubmed link https://pubmed.ncbi.nlm.nih.gov/20818904/ Publication month/year December 2019 Study question Assessing the effects of Olaparib in combination with bevacizumab on disease progression Type of study Randomized control trial Interventions compared Treatment with Olaparib and bevacizumab vs placebo and …

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