Ovarian Cancer Studies

Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup (GOG 182)

GOG 182 Study Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/19224846/ Publication month/year March 2009 Study question Does incorporation of an additional cytotoxic agent improve overall survival (OS) and progression-free survival (PFS) for women with advanced-stage epithelial ovarian …

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Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer (PAOLA-1)

PAOLA-1 Study Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer Disease site Ovaries  Fallopian tube Primary peritoneal Pubmed link https://pubmed.ncbi.nlm.nih.gov/20818904/ Publication month/year December 2019 Study question Assessing the effects of Olaparib in combination with bevacizumab on disease progression Type of study Randomized control trial Interventions compared Treatment with Olaparib and bevacizumab vs placebo and …

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Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer (GOG 172)

GOG 172 Study Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/16394300/ Publication month/year January, 2006 Study question The effectiveness of intraperitoneal Cisplatin and Paclitaxel in addition to intravenous Paclitaxel in women with stage III ovarian cancer who had optimal debulking surgery? Type of study Randomised controlled trial (RCT) Interventions compared …

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A Phase 3 Trial of Bevacizumab in Ovarian Cancer

ICON-7 Study A Phase 3 Trial of Bevacizumab in Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/22204725/ Publication month/year December 2011 Study question To investigate the addition of bevacizumab to standard chemotherapy in the first-line treatment of ovarian cancer Type of study Clinical trial Interventions compared Standard-chemotherapy group (carboplatin and paclitaxel)  Vs Standard Chemotherapy & …

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Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

HIPEC Study Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/29342393/ Publication month/year Jan 2018 Study question To investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial cancer. Type of study Multicenter, open-label, phase …

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Advanced Ovarian Cancer (GOG-178)

GOG 178 Study Phase III Randomized Trial of 12 Versus 3 Months of Maintenance Paclitaxel in Patients with Advanced Ovarian Cancer After Complete Response to Platinum and Paclitaxel-Based Chemotherapy: A Southwest Oncology Group and Gynecologic Oncology Group Trial Disease site Ovaries  Pubmed link https://pubmed.ncbi.nlm.nih.gov/12829663/ Publication month/year July, 2003 Study question To verify whether continuing paclitaxel …

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Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): A randomized, multicentre, open-label, phase 3 trial

MITO-7 StudyCarboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer; A randomized, multicentre, open-label, phase 3 trial Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/24582486/ Publication month/year February, 2014 Study question To assess whether a weekly schedule of carboplatin plus paclitaxel is more effective than the same drug combination given …

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Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer

VELIA Study Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/31562800/ Publication month/year September 2019 Study question Efficacy of Veliparib added to first-line induction chemotherapy with carboplatin and paclitaxel and continued as maintenance monotherapy in patients with previously untreated stage III or IV high-grade serous ovarian carcinoma. …

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ACTION Study

ACTION Study Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/12529344/ Publication month/year 2003 January Study question To comare the outcome platinum-based adjuvant chemotherapy with no further treatment (i.e., observation) following surgery in patients with early-stage ovarian cancer who had adequate surgical stage. Type of study Randomised controlled trial (RCT) Interventions compared Chemotherapy vs Observation Experimental arm (Intervention) …

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ICON1 Study

ICON1 Study International Collaborative Ovarian Neoplasm Trial 1: A Randomized Trial of Adjuvant Chemotherapy in Women With Early-Stage Ovarian Cancer (ICON1) Disease site Ovary Pubmed link https://pubmed.ncbi.nlm.nih.gov/12529345/ Publication month/year January 2003 Study question Can adjuvant chemotherapy improve overall survival and prolong recurrence-free survival in women with early-stage epithelial ovarian cancer? Type of study Randomised controlled …

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